Matthews Correlation Coefficient Comparison
Thus, 3DPocket was able to tie LIGSITE for the top place in terms of MCC (a statistic that combines the rate of true/false positives and true/false negatives) among other algorithms. This shows that the 3DPocket algorithm is very accurate and robust. However, a larger sample of proteins must be tested in order to definitively prove that 3DPocket is reliable and accurate. Additionally, testing it on a larger variety of proteins including DNA-binding proteins and enzymes would be beneficial, in order to reinforce its reliability.